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1

Substituent variation in azabicyclic triazole- and tetrazole-based muscarinic receptor ligands

Jenkins, Sarah M., Wadsworth, Harry J., Bromidge, Steven, Orlek, Barry S., Wyman, Paul A., Riley, Graham J., Hawkins, Julie

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 2.11 MB

english, 1992

2

Synthesis of ethyl 1-azabicyclo[2.2.1]hept-4-yl carboxylate

Barry S. Orlek, Harry Wadsworth, Paul Wyman, Frank D. King

Journal:

Tetrahedron Letters

Year:

1991

Language:

english

File:

PDF, 117 KB

english, 1991

3

Steric acceleration of intramolecular oxime and hydrazone cycloadditions

Bishop, Jane E., Flaxman, Katherine A., Orlek, Barry S., Sammes, Peter G., Weller, David J.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1995

Language:

english

File:

PDF, 624 KB

english, 1995

4

A Practical Synthesis of Differentially Protected 4,4′-Dipiperidinyl Ethers: Novel Ligands of Pharmaceutical Interest

Bailey, James, Bruton, Gordon, Huxley, Anthony, Johnstone, Vicky, Milner, Peter, Orlek, Barry, Stemp, Geoffrey

Journal:

Year:

2009

Language:

english

File:

PDF, 94 KB

english, 2009

5

Encyclopedia of Reagents for Organic Synthesis || N -Benzyl- N -(methoxymethyl)- N -trimethylsilylmethylamine

Orlek, Barry S.

Year:

2001

Language:

english

File:

PDF, 52 KB

english, 2001

6

Evaluation of a Series of Anticonvulsant 1,2,3,4-Tetrahydroisoquinolinyl-benzamides

Wai N. Chan, Michael S. Hadley, John D. Harling, Hugh J. Herdon, Barry S. Orlek, Graham J. Riley, Rachel E.A. Stead, Tania O. Stean, Mervyn Thompson, Neil Upton, Robert W. Ward

Journal:

Bioorganic & Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 415 KB

english, 2000

7

Characterisation of SB-221420-A — a neuronal Ca2+ and Na+ channel antagonist in experimental models of stroke

Colin A Campbell, Frank C Barone, Christopher D Benham, Sarah J Hadingham, Mark H Harries, John D Harling, Judith M Hills, V.Ann Lewis, Kenneth B Mackay, Barry S Orlek, Raymond F White, Andrew A Parso

Journal:

European Journal of Pharmacology

Year:

2000

Language:

english

File:

PDF, 383 KB

english, 2000

8

Design of [ R -( Z )]-(+)-α-(Methoxyimino)-1-azabicyclo[2.2.2]octane-3-acetonitrile (SB 202026), a Functionally Selective Azabicyclic Muscarinic M1 Agonist Incorporating the N -Methoxy Imidoyl Nitrile Group as a Novel Ester Bioisostere

Bromidge, Steven M., Brown, Frank, Cassidy, Frederick, Clark, Michael S. G., Dabbs, Steven, Hadley, Michael S., Hawkins, Julie, Loudon, Julia M., Naylor, Christopher B., Orlek, Barry S., Riley, Graham

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 461 KB

english, 1997

9

Lipopeptide substrates for SpsB, the Staphylococcus aureus type I signal peptidase: design, conformation and conversion to α-ketoamide inhibitors

Gordon Bruton, Anthony Huxley, Peter O'Hanlon, Barry Orlek, Drake Eggleston, John Humphries, Simon Readshaw, Andrew West, Stephen Ashman, Murray Brown, Keith Moore, Andrew Pope, Karen O'Dwyer, Lei Wan

Journal:

European Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 463 KB

english, 2003

10

Stereoselective construction of vicinal diamines. Part 1. Synthesis of fused pyrazines

Orlek, Barry S., Borrett, Gary T., Smith, Duncan M.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1993

Language:

english

File:

PDF, 937 KB

english, 1993

11

Design and synthesis of azabicyclic muscarinic agonists incorporating an oxime ether functionality

Steven M. Bromidge, Frank Brown, Frederick Cassidy, Michael S.G. Clark, Steven Dabbs, Michael S. Hadley, Julia M. Loudon, Barry S. Orlek, Graham J. Riley

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1992

Language:

english

File:

PDF, 306 KB

english, 1992

12

A novel and selective class of azabicyclic muscarinic agonists incorporating an N-methoxy imidoyl halide or nitrile functionality

Steven M. Bromidge, Frank Brown, Frederick Cassidy, Michael S.G. Clark, Steven Dabbs, Julie Hawkins, Julia M. Loudon, Barry S. Orlek, Graham J. Riley

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1992

Language:

english

File:

PDF, 394 KB

english, 1992

13

Synthesis and muscarinic activities of quinuclidin-3-yltriazole and -tetrazole derivatives

Wadsworth, Harry J., Jenkins, Sarah M., Orlek, Barry S., Cassidy, Frederick, Clark, Michael S. G., Brown, Frank, Riley, Graham J., Graves, Diane, Hawkins, Julie, Naylor, Christopher B.

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 2.25 MB

english, 1992

14

Stereoselective construction of vicinal diamines. Part 3.1 Routes to the benz[ f ]indeno[1,7-bc] azepine and benz[e]indeno[2,1-b][1,4]diazepine ring systems

Orlek, Barry S., Crowe, Eleanor A.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1997

Language:

english

File:

PDF, 70 KB

english, 1997

15

Steric acceleration of intramolecular cycloaddition reactions

Barry S. Orlek, Peter G. Sammes, David J. Weller

Journal:

Year:

1993

Language:

english

File:

PDF, 1.03 MB

english, 1993

16

Synthesis of α-silylalkylbenzoxazoles and oxazoles from stable silylketenes

Stephen P. Marsden, James T. Steer, Barry S. Orlek

Journal:

Year:

2009

Language:

english

File:

PDF, 356 KB

english, 2009

17

Penicillinase active sites: Labelling of serine-44 in β-lactamase I by 6β-bromopenicillanic acid

Vroni Knott-Hunziker, Stephen G. Waley, Barry S. Orlek, Peter G. Sammes

Journal:

Year:

1979

Language:

english

File:

PDF, 294 KB

english, 1979

18

ChemInform Abstract: Synthesis of α-Silylalkylbenzoxazoles and Oxazoles from Stable Silylketenes.

Stephen P. Marsden, James T. Steer, Barry S. Orlek

Journal:

Year:

2009

File:

PDF, 42 KB

2009

19

Bridged 1,2,5,6-tetrahydropyridine esters and oxime ethers related to arecoline are novel and potent muscarinic agonists

Steven M. Bromidge, Frederick Cassidy, Michael S.G. Clark, Richard E. Faulkner, Michael S. Hadley, Barry S. Orlek, Graham J. Riley, Geoffrey Stemp

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 431 KB

english, 1994

20

Use of steric buttresses to enhance intramolecular cycloadditions

Orlek, Barry S., Sammes, Peter G., Weller, David J.

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1993

Language:

english

File:

PDF, 225 KB

english, 1993

21

1,2,5,6-tetrahydropyridine oxime ethers incorporating electron withdrawing groups are potent and selective muscarinic agonists

Steven M. Bromidge, Frank Brown, Frederick Cassidy, Michael S.G. Clark, Emma J. Collings, Steven Dabbs, Richard E. Faulkner, Julia M. Loudon, Barry S. Orlek, Graham J. Riley

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 567 KB

english, 1994

22

A Stereoselective Route to trans-1-Arylthio-2-aminoindanes

Orlek, Barry S.

Journal:

Year:

1996

File:

PDF, 90 KB

1996

23

A stereoselective synthesis of 3-substituted hexahydroindeno[2,1-b]pyrroles via an intramolecular azomethine ylide cycloaddition

John D. Harling, Barry S. Orlek

Journal:

Year:

1998

Language:

english

File:

PDF, 422 KB

english, 1998

24

Steric acceleration of intramolecular azide cycloadditions

Orlek, Barry S., Sammes, Peter G., Weller, David J.

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1993

Language:

english

File:

PDF, 235 KB

english, 1993

25

On the chemistry of ?-lactamase inhibition by 6?-bromopenicillanic acid

Orlek, Barry S., Sammes, Peter G., Knott-Hunziker, Vroni, Waley, Stephen G.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1980

Language:

english

File:

PDF, 1.02 MB

english, 1980

26

Stereoselective synthesis of protected amines and diamines from alkenes using N,N-Dichloro-t-butylcarbamate

Barry S. Orlek, Geoffrey Stemp

Journal:

Tetrahedron Letters

Year:

1991

Language:

english

File:

PDF, 255 KB

english, 1991

27

Identification of a series of 1,2,3,4-tetrahydroisoquinolinyl- benzamides with potential anticonvulsant activity

Wai N. Chan, Michael S Hadley, John D. Harling, Hugh J. Herdon, Jeffrey C. Jerman, Barry S. Orlek, Tania O. Stean, Mervyn Thompson, Neil Upton, Robert W. Ward

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 218 KB

english, 1998

28

ChemInform Abstract: A Stereoselective Synthesis of 3-Substituted Hexahydroindeno[2,1-b]pyrroles via an Intramolecular Azomethine Ylide Cycloaddition.

John D. Harling, Barry S. Orlek

Journal:

Year:

1999

File:

PDF, 32 KB

1999

29

Design and synthesis of novel muscarinic agonists containing the 1,2,4-triazine ring as an ester bioisostere

Barry S. Orlek, Frederick Cassidy, Michael S.G. Clark, Richard E. Faulkner, Emma J. Collings, Julie Hawkins, Graham J. Riley

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 271 KB

english, 1994

30

Stereoselective synthesis of 1,2-diaminoindans: A novel approach to vicinal diamines

Journal:

Tetrahedron Letters

Year:

1986

Language:

english

File:

PDF, 187 KB

english, 1986

31

Comparison of azabicyclic esters and oxadiazoles as ligands for the muscarinic receptor

Rosenberg, Howard E., Wadsworth, Harry J., Wyman, Paul, Orlek, Barry S., Blaney, Frank E., Brown, Frank, Clark, Michael S. G., Hadley, Michael S., Hatcher, John, Riley, Graham J.

Journal:

Journal of Medicinal Chemistry

Year:

1991

Language:

english

File:

PDF, 2.09 MB

english, 1991

32

Stereoselective construction of vicinal diamines. Part 2. Synthesis of indenopyrazines

Orlek, Barry S., Lightowler, Diane

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1993

Language:

english

File:

PDF, 750 KB

english, 1993

33

Diastereoselective routes to endo and exo ethyl 1-azabicyclo[2.2.1] hept-3-YL carboxylates

Barry S. Orlek, Harry Wadsworth, Paul Wyman, Michael S. Hadley

Journal:

Tetrahedron Letters

Year:

1991

Language:

english

File:

PDF, 218 KB

english, 1991

34

On the chemical binding of 6?-bromopenicillanic acid to ?-lactamase I

Orlek, Barry S., Sammes, Peter G., Knott-Hunziker, Vroni, Waley, Stephen G.

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1979

Language:

english

File:

PDF, 186 KB

english, 1979

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